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Casein kinase 1 isoform epsilon : ウィキペディア英語版 | Casein kinase 1 isoform epsilon
Casein kinase I isoform epsilon or CK1ε, is an enzyme that in humans is encoded by the ''CSNK1E'' gene. CK1ε is a serine/threonine protein kinase and is very highly conserved; therefore, this kinase is very similar to other members of the casein kinase 1 family.〔 This gene is a major component of the mammalian oscillator which controls cellular circadian rhythms.〔 == Discovery == The human CK1ε was first isolated and cloned in 1995, officially identified as an isoform of the casein kinase 1 family. Three transcript variants encoding the same protein have been found for this gene in rat: CK1ε1, CK1ε2, and CK1ε3; and two have been found in humans.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454 )〕 In humans, the CSNK1E gene localizes at 22q13.1 and consists of 12 exons.〔
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